Your Name: Benjamin Fox

Theme: Haematological changes in systemic disease

OPTION LIST

A	Anaemia of chronic disease	I	Polymyalgia rheumatica
B	Diverticular disease	J	Rheumatoid arthritis
C	Eosinophils	K	Sarcoidosis
D	Iron deficiency anaemia	L	Systemic lupus erythematosis
E	Leucoerythroblastic anaemia	M
F	Microangiopathic haemolytic anaemia	N
G	Monocytes	O
H	Neutrophils	P

For each scenario below, choose the most appropriate answer from the list above. Each option may be used once, more than once or not at all.

1. A 61 year old lady complains to her GP of morning stiffness and aching in her hips. She also suffers from anorexia, fatigue and occasional night sweats. She is found to have a raised ESR. Of note she has had giant cell arterititis in the past. What is the most likely diagnosis from the list above.

2. An 81 year old man with known prostatic carcinoma presents to his GP with severe bone pain. Blood tests reveal a mild anaemia and peripheral blood film shows nucleated red blood cells and immature myeloid cells. What are these haematological features collectively known as?

3. A 51 year old man is having work up for palliative surgery due to gastric adenocarcinoma. He is found to be anaemic, with high a reticulocyte count and fragmented red blood cells on blood smear. What is this anaemia known as?

4. A 21 year old student recently returning from India complains to his GP of cough, headache and diarrhoea. He is febrile and rose spots are present on his chest. Blood culture reveals salmonella typhi. Which immune cells out of the list are most likely to be raised?

5. Anaemia and neutropenia are more common in which of the above autoimmune disease?

ANSWERS

1. I

2. E

3. F

4. G

5. L